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KMID : 0354720060300060459
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Journal of Korean Diabetes Association
2006 Volume.30 No. 6 p.459 ~ p.465
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Effect of Sea Tangle Powder on the Regulation of Blood Glucose Level and Body Weight in Streptozotocin (STZ)-induced Diabetic Rats
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Kim Hyung-Woo
Kang Jae-Seung
Kim Su-In
Lee Wang-Jae
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Abstract
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Background: Sea tangle is one of the low calorie diet and the fibers in sea tangle suppress the increase of blood glucose level. Therefore, it has a better impact than any other diets for diabetic patients. In the present study, we have investigated the effect of sea tangle powder, hereafter referred as Substance , as an antihyperglycemic agent and
antioxidant in streptozotocin (STZ)-induced diabetic rats.
Methods: Male Wistar rats were divided into three groups: group 1) vehicle-treated normal rats; group 2) vehicle-treated STZ-diabetic rats; group 3) sea tangle powder-treated STZ-diabetic rats. Fasting blood glucose levels and body weights were measured. Intracellular ROS levels were measured using Cytofluor 2350 plate reader.
Results:Oral administration of sea tangle powder for 10 days resulted in lowered levels of blood glucose in early stage (within a week) and preventing effect of weight loss in late stage. Treatment with sea tangle powder resulted in the decrease of intracellular ROS levels in Dendritic Cell line.
Conclusion: Sea tangle powder exhibits antihyperglycemic activity and restorative activity on weight loss in STZ-induced diabetic rats. It’s abilities depend not on protecting disruption of β-cell, but on antioxidant effect in other organs.
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KEYWORD
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Antioxidant, Diabetes mellitus, Sea tangle powder
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